Structural basis for the recognition of human hemoglobin by the heme-acquisition protein Shr from Streptococcus pyogenes. Akinobu Senoo, Masato Hoshino, Toshiki Shiomi, Makoto Nakakido, Satoru Nagatoishi, Daisuke Kuroda, Ichiro Nakagawa, Jeremy R H Tame, Jose M M Caaveiro, Kouhei Tsumoto. Sci Rep. 2024 Mar 5;14(1):5374. doi: 10.1038/s41598-024-55734-x.

Characterization of pig tonsils as niches for the generation of Streptococcus suis diversity. Kai Kobayashi, Hiroaki Kubota, Mari Tohya, Megumi Ushikubo, Miki Yamamoto, Tsukasa Ariyoshi, Yumi Uchitani, Morika Mitobe, Rumi Okuno, Ichiro Nakagawa, Tsutomu Sekizaki, Jun Suzuki, Kenji Sadamasu. Vet Res. 2024 Feb 6;55(1):17. doi: 10.1186/s13567-024-01270-5.

Group A Streptococcus cation diffusion facilitator proteins contribute to immune evasion by regulating intracellular metal concentrations. Chihiro Aikawa, Akihide Shimizu, Makoto Nakakido, Kazunori Murase, Takashi Nozawa, Kouhei Tsumoto, Ichiro Nakagawa. Biochem Biophys Res Commun. 2023 Oct 8;676:141-148. doi: 10.1016/j.bbrc.2023.07.052.

Rab41-mediated ESCRT machinery repairs membrane rupture by a bacterial toxin in xenophagy. Takashi Nozawa, Hirotaka Toh, Junpei Iibushi, Kohei Kogai, Atsuko Minowa-Nozawa, Junko Satoh, Shinji Ito, Kazunori Murase, Ichiro Nakagawa. Nat Commun. 2023 Oct 6;14(1):6230. doi: 10.1038/s41467-023-42039-2.

Anti-InlA single-domain antibodies that inhibit the cell invasion of Listeria monocytogenes. Taichi Yamazaki, Satoru Nagatoishi, Tsukushi Yamawaki, Takashi Nozawa, Ryo Matsunaga, Makoto Nakakido, Jose M.M. Caaveiro, Ichiro Nakagawa, Kouhei Tsumoto. J Biol Chem. 2023 Sep 14;105254. doi: 10.1016/j.jbc.2023.105254.

Targeting hemoglobin receptors IsdH and IsdB of Staphylococcus aureus with a single VHH antibody inhibits bacterial growth. Sandra Valenciano-Bellido, Jose M M Caaveiro, Makoto Nakakido, Daisuke Kuroda, Chihiro Aikawa, Ichiro Nakagawa, Kouhei Tsumoto. J Biol Chem. 2023 Jun 15;104927. doi: 10.1016/j.jbc.2023.104927.

Clonal Expansion of Multidrug-Resistant Streptococcus dysgalactiae Subspecies equisimilis Causing Bacteremia, Japan, 2005-2021. Koh Shinohara, Kazunori Murase, Yasuhiro Tsuchido, Taro Noguchi, Satomi Yukawa, Masaki Yamamoto, Yasufumi Matsumura, Ichiro Nakagawa, Miki Nagao. Emerg Infect Dis. 2023 Mar;29(3):528-539. doi: 10.3201/eid2903.221060.

Guanylate-Binding Protein 1 Regulates Infection-Induced Autophagy through TBK1 Phosphorylation. Miyako Hikichi, Hirotaka Toh, Atsuko Minowa-Nozawa, Takashi Nozawa, Ichiro Nakagawa. Cell Microbiol. 2022 May. doi: 10.1155/2022/8612113.

Genomic dissection of the Vibrio cholerae O-serogroup global reference strains: reassessing our view of diversity and plasticity between two chromosomes. Kazunori Murase, Eiji Arakawa, Hidemasa Izumiya, Atsushi Iguchi, Taichiro Takemura, Taisei Kikuchi, Ichiro Nakagawa, Nicholas R Thomson, Makoto Ohnishi, Masatomo Morita. Microb Genom. 2022 Aug;8(8):mgen000860. doi: 10.1099/mgen.0.000860.

Global population structure of the Serratia marcescens complex and identification of hospital-adapted lineages in the complex. Tomoyuki Ono, Itsuki Taniguchi, Keiji Nakamura, Debora Satie Nagano, Ruriko Nishida, Yasuhiro Gotoh, Yoshitoshi Ogura, Mitsuhiko P Sato, Atsushi Iguchi, Kazunori Murase, Dai Yoshimura, Takehiko Itoh, Ayaka Shima, Damien Dubois, Eric Oswald, Akira Shiose, Naomasa Gotoh, Tetsuya Hayashi. Microb Genom. 2022 Mar;8(3):000793. doi: 10.1099/mgen.0.000793.

Complete Genome Sequences of Three Streptococcus ruminantium Strains Obtained from Endocarditis Lesions of Cattle in Japan. Ryohei Nomoto, Kasumi Ishida-Kuroki, Mari Tohya, Ichiro Nakagawa, Tsutomu Sekizaki. Microbiol Resour Announc. 2022 May 19;11(5):e0124821. doi: 10.1128/mra.01248-21.

Complete Genome Sequences of Four Streptococcus parasuis Strains Obtained from Saliva of Domestic Pigs in Japan. Ryohei Nomoto, Kasumi Ishida-Kuroki, Ichiro Nakagawa, Tsutomu Sekizaki. Microbiol Resour Announc. 2022 Feb 17;11(2):e0124521.doi: 10.1128/mra.01245-21.

FBXO2/SCF ubiquitin ligase complex directs xenophagy through recognizing bacterial surface glycan. Akihiro Yamada, Miyako Hikichi, Takashi Nozawa, Ichiro Nakagawa. EMBO Rep. 2021 Nov 4;22(11):e52584. doi: 10.15252/embr.202152584.

The global population structure and evolutionary history of the acquisition of major virulence factor-encoding genetic elements in Shiga toxin-producing Escherichia coli O121:H19. Ruriko Nishida, Keiji Nakamura, Itsuki Taniguchi, Kazunori Murase, Tadasuke Ooka, Yoshitoshi Ogura, Yasuhiro Gotoh, Takehiko Itoh, Atsushi Toyoda, Jacques Georges Mainil, Denis Piérard, Kazuko Seto, Tetsuya Harada, Junko Isobe, Keiko Kimata, Yoshiki Etoh, Mitsuhiro Hamasaki, Hiroshi Narimatsu, Jun Yatsuyanagi, Mitsuhiro Kameyama, Yuko Matsumoto, Yuhki Nagai, Jun Kawase, Eiji Yokoyama, Kazuhiko Ishikawa, Takayuki Shiomoto, Kenichi Lee, Dongchon Kang, Koichi Akashi, Makoto Ohnishi, Sunao Iyoda, Tetsuya Hayashi. Microb Genom. 2021 Dec;7(12):000716. doi: 10.1099/mgen.0.000716.

Patient-specific establishment of bacterial composition within the peri-implant microbiota during the earliest weeks after implant uncovering. Masahiro Shimogishi, Takayasu Watanabe, Masaki Shibasaki, Takahiko Shiba, Keiji Komatsu, Takashi Nemoto, Kazuyuki Ishihara, Yoshio Nakano, Takanori Iwata, Shohei Kasugai, Ichiro Nakagawa. J Periodontal Res. 2021 Oct;56(5):964-971. doi: 10.1111/jre.12898.

An In Vitro Mixed Infection Model With Commensal and Pathogenic Staphylococci for the Exploration of Interspecific Interactions and Their Impacts on Skin Physiology. Katsunori Kohda, Xuan Li, Naoki Soga, Risa Nagura, Tie Duerna, Saeko Nakajima, Ichiro Nakagawa, Masakazu Ito, Akinori Ikeuchi. Front Cell Infect Microbiol. 2021 Sep 16;11:712360. doi: 10.3389/fcimb.2021.712360.

Correction: Significance of a histone-like protein with its native structure for the diagnosis of asymptomatic tuberculosis. Yukiko Ohara, Yuriko Ozeki, Yoshitaka Tateishi, Tsukasa Mashima, Fumio Arisaka, Yasuo Tsunaka, Yoshie Fujiwara, Akihito Nishiyama, Yutaka Yoshida, Kengo Kitadokoro, Haruka Kobayashi, Yukihiro Kaneko, Ichiro Nakagawa, Ryoji Maekura, Saburo Yamamoto, Masato Katahira, Sohkichi Matsumoto. PLoS One. 2021 Aug 27;16(8):e0256946. doi: 10.1371/journal.pone.0256946.

Single-chain variable fragment (scFv) targeting streptolysin O controls group A Streptococcus infection. Chihiro Aikawa, Kiyosumi Kawashima, Chihiro Fukuzaki, Makoto Nakakido, Kazunori Murase, Takashi Nozawa, Kouhei Tsumoto, Ichiro Nakagawa. Biochem Biophys Res Commun. 2021 Aug 20;566:177-183. doi: 10.1016/j.bbrc.2021.06.021.

Characterization of a putative maltodextrin-binding protein of Streptococcus pyogenes, SPs0871 and the development of a VHH inhibitor. Tsukushi Yamawaki, Makoto Nakakido, Kan Ujiie, Chihiro Aikawa, Ichiro Nakagawa, Kouhei Tsumoto. Biochem Biophys Res Commun. 2021 Aug 6;565:1-7. doi: 10.1016/j.bbrc.2021.05.056.

Biological Effect of Streptococcus pyogenes-Released Extracellular Vesicles on Human Monocytic Cells, Induction of Cytotoxicity, and Inflammatory Response. Kazunori Murase, Chihiro Aikawa, Takashi Nozawa, Ayako Nakatake, Kuniyo Sakamoto, Taisei Kikuchi, Ichiro Nakagawa. Front Cell Infect Microbiol. 2021 Jul 19;11:711144. doi: 10.3389/fcimb.2021.711144.

Intracellular Group A Streptococcus Induces Golgi Fragmentation To Impair Host Defenses through Streptolysin O and NAD-Glycohydrolase. Takashi Nozawa, Junpei Iibushi, Hirotaka Toh, Atsuko Minowa-Nozawa, Kazunori Murase, Chihiro Aikawa, Ichiro Nakagawa. mBio. 2021 Feb 9;12(1):e01974-20. doi: 10.1128/mBio.01974-20.　京都大学プレスリリース：人食いバクテリアの新たな免疫回避機構を発見

Autophagy Receptor Tollip Facilitates Bacterial Autophagy by Recruiting Galectin-7 in Response to Group A Streptococcus Infection. Ching-Yu Lin, Takashi Nozawa, Atsuko Minowa-Nozawa, Hirotaka Toh, Miyako Hikichi, Junpei Iibushi, Ichiro Nakagawa. Front Cell Infect Microbiol. 2020 Dec 23;10:583137. doi: 10.3389/fcimb.2020.583137.

Differential dynamics and impacts of prophages and plasmids on the pangenome and virulence factor repertoires of Shiga toxin-producing Escherichia coli O145:H28. Keiji Nakamura, Kazunori Murase, Mitsuhiko P Sato, Atsushi Toyoda, Takehiko Itoh, Jacques Georges Mainil, Denis Piérard, Shuji Yoshino, Keiko Kimata, Junko Isobe, Kazuko Seto, Yoshiki Etoh, Hiroshi Narimatsu, Shioko Saito, Jun Yatsuyanagi, Kenichi Lee, Sunao Iyoda, Makoto Ohnishi, Tadasuke Ooka, Yasuhiro Gotoh, Yoshitoshi Ogura, Tetsuya Hayashi. Microb Genom. 2020 Jan;6(1):e000323. doi: 10.1099/mgen.0.000323.

Complete Genome Sequences of Two Streptococcus suis Strains Isolated from Asymptomatic Pigs. Atsuko Minowa-Nozawa, Takashi Nozawa, Daisuke Takamatsu, Akemi Yoshida, Kazunori Murase, Taisei Kikuchi, Kasumi Ishida-Kuroki, Yoshihiro Nitta, Tsutomu Sekizaki, Ichiro Nakagawa. Microbiol Resour Announc. 2020 Nov 19;9(47):e01142-20. doi: 10.1128/MRA.01142-20.

Complete Genome Sequences of Streptococcus pyogenes Serotype M3, M28, and M89 Strains Isolated from Human Patients in Japan, 1994 to 2009. Kazunori Murase, Takashi Nozawa, Chihiro Aikawa, Miki Nagao, Tadayoshi Ikebe, Akemi Yoshida, Taisei Kikuchi, Ichiro Nakagawa. Microbiol Resour Announc. 2020 Oct 15;9(42):e01047-20. doi: 10.1128/MRA.01047-20.

Phylogenetic diversity in fim and mfa gene clusters between Porphyromonas gingivalis and Porphyromonas gulae, as a potential cause of host specificity. Kaori Fujiwara-Takahashi, Takayasu Watanabe, Masahiro Shimogishi, Masaki Shibasaki, Makoto Umeda, Yuichi Izumi, Ichiro Nakagawa. J Oral Microbiol. 2020 Jun 19;12(1):1775333. doi: 10.1080/20002297.2020.1775333.

Complete Genome Sequence of Helicobacter pylori Strain ATCC 43504, a Type Strain That Can Infect Gerbils. Ryo Kinoshita-Daitoku, Yoshitoshi Ogura, Kotaro Kiga, Fumito Maruyama, Tomoyo Kondo, Ichiro Nakagawa, Tetsuya Hayashi, Hitomi Mimuro. Microbiol Resour Announc. 2020 Apr 30;9(18):e00105-20. doi: 10.1128/MRA.00105-20.

Group A Streptococcus establishes pharynx infection by degrading the deoxyribonucleic acid of neutrophil extracellular traps. Mototsugu Tanaka, Ryo Kinoshita-Daitoku, Kotaro Kiga, Takahito Sanada, Bo Zhu, Tokuju Okano, Chihiro Aikawa, Tamako Iida, Yoshitoshi Ogura, Tetsuya Hayashi, Koshu Okubo, Miho Kurosawa, Junichi Hirahashi, Toshihiko Suzuki, Ichiro Nakagawa, Masaomi Nangaku, Hitomi Mimuro. Sci Rep. 2020 Feb 24;10(1):3251. doi: 10.1038/s41598-020-60306-w.

TBC1D9 regulates TBK1 activation through Ca 2+ signaling in selective autophagy. Takashi Nozawa, Shunsuke Sano, Atsuko Minowa-Nozawa, Hirotaka Toh, Shintaro Nakajima, Kazunori Murase, Chihiro Aikawa, Ichiro Nakagawa. Nat Commun. 2020 Feb 7;11(1):770. doi: 10.1038/s41467-020-14533-4.

Persistent colonization of non-lymphoid tissue-resident macrophages by Stenotrophomonas maltophilia. Ichiro Takahashi, Koji Hosomi, Takahiro Nagatake, Hirokazu Toubou, Daiki Yamamoto, Ikue Hayashi, Yosuke Kurashima, Shintaro Sato, Naoko Shibata, Yoshiyuki Goto, Fumito Maruyama, Ichiro Nakagawa, Asaomi Kuwae, Akio Abe, Jun Kunisawa, Hiroshi Kiyono. Int Immunol. 2020 Feb 7;32(2):133-141. doi: 10.1093/intimm/dxz071.

Group A Streptococcus modulates RAB1- and PIK3C3 complex-dependent autophagy. Hirotaka Toh, Takashi Nozawa, Atsuko Minowa-Nozawa, Miyako Hikichi, Shintaro Nakajima, Chihiro Aikawa, Ichiro Nakagawa. Autophagy. 2020 Feb;16(2):334-346. doi: 10.1080/15548627.2019.1628539.

Identification of Group A Streptococcus-Containing Autophagosome-Like Vacuoles. Takashi Nozawa, Ichiro Nakagawa. Methods Mol Biol. 2020;2136:223-231. doi: 10.1007/978-1-0716-0467-0_16.

Reduced Genome of the Gut Symbiotic Bacterium “Candidatus Benitsuchiphilus tojoi” Provides Insight Into Its Possible Roles in Ecology and Adaptation of the Host Insect. Shakhinur Islam Mondal, Arzuba Akter, Ryuichi Koga, Takahiro Hosokawa, Mehmet Dayi, Kazunori Murase, Ryusei Tanaka, Shuji Shigenobu, Takema Fukatsu, Taisei Kikuchi. Front Microbiol. 2020 May 6;11:840. doi: 10.3389/fmicb.2020.00840. eCollection 2020.

Group A Streptococcus NAD-Glycohydrolase Inhibits Caveolin 1-Mediated Internalization Into Human Epithelial Cells. Hirotaka Toh, Ching-Yu Lin, Shintaro Nakajima, Chihiro Aikawa, Takashi Nozawa, Ichiro Nakagawa. Front Cell Infect Microbiol. 2019 Nov 28;9:398. doi: 10.3389/fcimb.2019.00398.

Complete Genome Sequences of Eight Methicillin-Resistant Staphylococcus aureus Strains Isolated from Patients in Japan. Miyako Hikichi, Miki Nagao, Kazunori Murase, Chihiro Aikawa, Takashi Nozawa, Akemi Yoshida, Taisei Kikuchi, Ichiro Nakagawa. Microbiol Resour Announc. 2019 Nov 21;8(47):e01212-19. doi: 10.1128/MRA.01212-19.

16S rRNA Gene Amplicon Sequence Data from Chicken Cecal Feces from Vietnam and Thailand. Nachiko Takeshita, Hyunjung Kim, Kringkrai Witoonsatian, Mari Tohya, Tấn Hùng Võ, Nuchjaree Boonyong, Thị Phương Bình Nguyễn, Ichiro Nakagawa, Nattakan Meekhanon, Ngọc Hải Nguyễn, Tsutomu Sekizaki. Microbiol Resour Announc. 2019 Aug 8;8(32):e00781-19. doi: 10.1128/MRA.00781-19.

Characterization of pig saliva as the major natural habitat of Streptococcus suis by analyzing oral, fecal, vaginal, and environmental microbiota. Kazunori Murase, Takayasu Watanabe, Sakura Arai, Hyunjung Kim, Mari Tohya, Kasumi Ishida-Kuroki, Tấn Hùng Võ, Thị Phương Bình Nguyễn, Ichiro Nakagawa, Ro Osawa, Ngọc Hải Nguyễn, Tsutomu Sekizaki. PLoS One. 2019 Apr 24;14(4):e0215983. doi: 10.1371/journal.pone.0215983.

LAMTOR2/LAMTOR1 complex is required for TAX1BP1-mediated xenophagy. Ching-Yu Lin, Takashi Nozawa, Atsuko Minowa-Nozawa, Hirotaka Toh, Chihiro Aikawa, Ichiro Nakagawa. Cell Microbiol. 2019 Apr;21(4):e12981. doi: 10.1111/cmi.12981.

Functional dysbiosis within dental plaque microbiota in cleft lip and palate patients. Kenta Funahashi, Takahiko Shiba, Takayasu Watanabe, Keiko Muramoto, Yasuo Takeuchi, Takuya Ogawa, Yuichi Izumi, Tsutomu Sekizaki, Ichiro Nakagawa, Keiji Moriyama. Prog Orthod. 2019 Mar 25;20(1):11. doi: 10.1186/s40510-019-0265-1.

RAB30 regulates PI4KB (phosphatidylinositol 4-kinase beta)-dependent autophagy against group A Streptococcus. Koji Nakajima, Takashi Nozawa, Atsuko Minowa-Nozawa, Hirotaka Toh, Shunsuke Yamada, Chihiro Aikawa, Ichiro Nakagawa. Autophagy. 2019 Mar;15(3):466-477. doi: 10.1080/15548627.2018.1532260.

Complete Genome Sequences of Streptococcus pneumoniae Strains HU-OH (Serotype 3, Sequence Type 183 [ST183]), NU83127 (Serotype 4, ST246), and ATCC 49619 (Serotype 19F, ST1203). Kentaro Nagaoka, Satoshi Konno, Kazunori Murase, Taisei Kikuchi, Yoshitomo Morinaga, Katsunori Yanagihara, Ichiro Nakagawa. Microbiol Resour Announc. 2019 Feb 28;8(9):e01504-18. doi: 10.1128/MRA.01504-18.

Improved 18S and 28S rDNA primer sets for NGS-based parasite detection. Asuka Kounosu, Kazunori Murase, Akemi Yoshida, Haruhiko Maruyama, Taisei Kikuchi. Sci Rep. 2019 Oct 31;9(1):15789. doi: 10.1038/s41598-019-52422-z.

Phylogenetic relationship of prophages is affected by CRISPR selection in Group A Streptococcus. Shunsuke Yamada, Masaki Shibasaki, Kazunori Murase, Takayasu Watanabe, Chihiro Aikawa, Takashi Nozawa, Ichiro Nakagawa. BMC Microbiol. 2019 Jan 28;19(1):24. doi: 10.1186/s12866-019-1393-y.

Biology and genome of a newly discovered sibling species of Caenorhabditis elegans. Natsumi Kanzaki, Isheng J Tsai, Ryusei Tanaka, Vicky L Hunt, Dang Liu, Kenji Tsuyama, Yasunobu Maeda, Satoshi Namai, Ryohei Kumagai, Alan Tracey, Nancy Holroyd, Stephen R Doyle, Gavin C Woodruff, Kazunori Murase, Hiromi Kitazume, Cynthia Chai, Allison Akagi, Oishika Panda, Huei-Mien Ke, Frank C Schroeder, John Wang, Matthew Berriman, Paul W Sternberg, Asako Sugimoto, Taisei Kikuchi. Nat Commun. 2018 Aug 10;9(1):3216. doi: 10.1038/s41467-018-05712-5.

Complete Genome Sequence of Streptococcus agalactiae Serotype III, Multilocus Sequence Type 335 Strain HU-GS5823, Isolated from a Human Patient in Japan with Severe Invasive Infection. Kentaro Nagaoka, Satoshi Konno, Kazunori Murase, Taisei Kikuchi, Ichiro Nakagawa. Microbiol Resour Announc. 2018 Nov 21;7(20):e01303-18. doi: 10.1128/MRA.01303-18.

NLRX1 Negatively Regulates Group A Streptococcus Invasion and Autophagy Induction by Interacting With the Beclin 1-UVRAG Complex. Chihiro Aikawa, Shintaro Nakajima, Miho Karimine, Takashi Nozawa, Atsuko Minowa-Nozawa, Hirotaka Toh, Shunsuke Yamada, Ichiro Nakagawa. Front Cell Infect Microbiol. 2018 Nov 14;8:403. doi: 10.3389/fcimb.2018.00403.

Significance of a histone-like protein with its native structure for the diagnosis of asymptomatic tuberculosis. Yukiko Ohara, Yuriko Ozeki, Yoshitaka Tateishi, Tsukasa Mashima, Fumio Arisaka, Yasuo Tsunaka, Yoshie Fujiwara, Akihito Nishiyama, Yutaka Yoshida, Kengo Kitadokoro, Haruka Kobayashi, Yukihiro Kaneko, Ichiro Nakagawa, Ryoji Maekura, Saburo Yamamoto, Masato Katahira, Sohkichi Matsumoto. PLoS One. 2018 Oct 25;13(10):e0204160. doi: 10.1371/journal.pone.0204160.

Assessment of pig saliva as a Streptococcus suis reservoir and potential source of infection on farms by use of a novel quantitative polymerase chain reaction assay. Sakura Arai, Hyunjung Kim, Takayasu Watanabe, Mari Tohya, Eriko Suzuki, Kasumi Ishida-Kuroki, Fumito Maruyama, Kazunori Murase, Ichiro Nakagawa, Tsutomu Sekizaki. Am J Vet Res. 2018 Sep;79(9):941-948. doi: 10.2460/ajvr.79.9.941.

Vibrio cholerae embraces two major evolutionary traits as revealed by targeted gene sequencing. Kazuhisa Okada, Warawan Wongboot, Siriporn Chantaroj, Wirongrong Natakuathung, Amonrattana Roobthaisong, Watcharaporn Kamjumphol, Fumito Maruyama, Taichiro Takemura, Ichiro Nakagawa, Makoto Ohnishi, Shigeyuki Hamada. Sci Rep. 2018 Jan 26;8(1):1631. doi: 10.1038/s41598-018-19995-7.

Biophysical characterization of the interaction between heme and proteins responsible for heme transfer in Streptococcus pyogenes. Masato Hoshino, Makoto Nakakido, Satoru Nagatoishi, Chihiro Aikawa, Ichiro Nakagawa, Kouhei Tsumoto. Biochem Biophys Res Commun. 2017 Nov 18;493(2):1109-1114. doi: 10.1016/j.bbrc.2017.09.055.

Rab35 GTPase recruits NDP52 to autophagy targets. Atsuko Minowa-Nozawa, Takashi Nozawa, Keiko Okamoto-Furuta, Haruyasu Kohda, Ichiro Nakagawa. EMBO J. 2017 Nov 15;36(22):3405. doi: 10.15252/embj.201798293.

Genetic diversity of environmental Vibrio cholerae O1 strains isolated in Northern Vietnam. Taichiro Takemura, Kazunori Murase, Fumito Maruyama, Thi Luong Tran, Atsushi Ota, Ichiro Nakagawa, Dong Tu Nguyen, Tu Cuong Ngo, Thi Hang Nguyen, Asako Tokizawa, Masatomo Morita, Makoto Ohnishi, Binh Minh Nguyen, Tetsu Yamashiro. Infect Genet Evol. 2017 Oct;54:146-151. doi: 10.1016/j.meegid.2017.06.017.

Rab35 GTPase recruits NDP52 to autophagy targets. Atsuko Minowa-Nozawa, Takashi Nozawa, Keiko Okamoto-Furuta, Haruyasu Kohda, Ichiro Nakagawa. EMBO J. 2017 Sep 15;36(18):2790-2807. doi: 10.15252/embj.201796463.

Population Structure and Local Adaptation of MAC Lung Disease Agent Mycobacterium avium subsp. Hominissuis. Hirokazu Yano, Tomotada Iwamoto, Yukiko Nishiuchi, Chie Nakajima, Daria A Starkova, Igor Mokrousov, Olga Narvskaya, Shiomi Yoshida, Kentaro Arikawa, Noriko Nakanishi, Ken Osaki, Ichiro Nakagawa, Manabu Ato, Yasuhiko Suzuki, Fumito Maruyama. Genome Biol Evol. 2017 Sep 1;9(9):2403-2417. doi: 10.1093/gbe/evx183.

Investigation of potential targets of Porphyromonas CRISPRs among the genomes of Porphyromonas species. Takayasu Watanabe, Masaki Shibasaki, Fumito Maruyama, Tsutomu Sekizaki, Ichiro Nakagawa. PLoS One. 2017 Aug 24;12(8):e0183752. doi: 10.1371/journal.pone.0183752.

A Locus Encoding Variable Defense Systems against Invading DNA Identified in Streptococcus suis. Masatoshi Okura, Takashi Nozawa, Takayasu Watanabe, Kazunori Murase, Ichiro Nakagawa, Daisuke Takamatsu, Makoto Osaki, Tsutomu Sekizaki, Marcelo Gottschalk, Shigeyuki Hamada, Fumito Maruyama. Genome Biol Evol. 2017 Apr 1;9(4):1000-1012. doi: 10.1093/gbe/evx062.

YvqE and CovRS of Group A Streptococcus Play a Pivotal Role in Viability and Phenotypic Adaptations to Multiple Environmental Stresses. Amonrattana Roobthaisong, Chihiro Aikawa, Takashi Nozawa, Fumito Maruyama, Ichiro Nakagawa. PLoS One. 2017 Jan 25;12(1):e0170612. doi: 10.1371/journal.pone.0170612.

Bcl-xL Affects Group A Streptococcus-Induced Autophagy Directly, by Inhibiting Fusion between Autophagosomes and Lysosomes, and Indirectly, by Inhibiting Bacterial Internalization via Interaction with Beclin 1-UVRAG. Shintaro Nakajima, Chihiro Aikawa, Takashi Nozawa, Atsuko Minowa-Nozawa, Hirotaka Toh, Ichiro Nakagawa. PLoS One. 2017 Jan 13;12(1):e0170138. doi: 10.1371/journal.pone.0170138.

The STX6-VTI1B-VAMP3 complex facilitates xenophagy by regulating the fusion between recycling endosomes and autophagosomes. Takashi Nozawa, Atsuko Minowa-Nozawa, Chihiro Aikawa, Ichiro Nakagawa. Autophagy. 2017 Jan 2;13(1):57-69. doi: 10.1080/15548627.2016.1241924.

The intracellular microbial sensor NLRP4 directs Rho-actin signaling to facilitate Group A Streptococcus-containing autophagosome-like vacuole formation. Takashi Nozawa, Chihiro Aikawa, Atsuko Minowa-Nozawa, Ichiro Nakagawa. Autophagy. 2017;13(11):1841-1854. doi: 10.1080/15548627.2017.1358343.

HlyF Produced by Extraintestinal Pathogenic Escherichia coli Is a Virulence Factor That Regulates Outer Membrane Vesicle Biogenesis. Kazunori Murase, Patricia Martin, Gaëlle Porcheron, Sébastien Houle, Emmanuelle Helloin, Marie Pénary, Jean-Philippe Nougayrède, Charles M Dozois, Tetsuya Hayashi, Eric Oswald. J Infect Dis. 2016 Mar 1;213(5):856-65. doi: 10.1093/infdis/jiv506. Epub 2015 Oct 22.

DNA-based culture-independent analysis detects the presence of group a streptococcus in throat samples from healthy adults in Japan. Tejaswini Kulkarni, Chihiro Aikawa, Takashi Nozawa, Kazunori Murase, Fumito Maruyama, Ichiro Nakagawa. BMC Microbiol. 2016 Oct 11;16(1):237. doi: 10.1186/s12866-016-0858-5.

Distinct interacting core taxa in co-occurrence networks enable discrimination of polymicrobial oral diseases with similar symptoms. Takahiko Shiba, Takayasu Watanabe, Hirokazu Kachi, Tatsuro Koyanagi, Noriko Maruyama, Kazunori Murase, Yasuo Takeuchi, Fumito Maruyama, Yuichi Izumi, Ichiro Nakagawa. Sci Rep. 2016 Aug 8;6:30997. doi: 10.1038/srep30997.

Comparative Genome Analyses of Streptococcus suis Isolates from Endocarditis Demonstrate Persistence of Dual Phenotypic Clones. Mari Tohya, Takayasu Watanabe, Fumito Maruyama, Sakura Arai, Atsushi Ota, Taryn B T Athey, Nahuel Fittipaldi, Ichiro Nakagawa, Tsutomu Sekizaki. PLoS One. 2016 Jul 19;11(7):e0159558. doi: 10.1371/journal.pone.0159558.

Complete Genome Sequences of Broad-Host-Range Pseudomonas aeruginosa Bacteriophages ΦR18 and ΦS12-1. Takaaki Furusawa, Hidetomo Iwano, Hidetoshi Higuchi, Masaru Usui, Fumito Maruyama, Ichiro Nakagawa, Hiroshi Yokota, Yutaka Tamura. Genome Announc. 2016 May 5;4(3):e00041-16. doi: 10.1128/genomeA.00041-16.

Microbially cleaved immunoglobulins are sensed by the innate immune receptor LILRA2. Kouyuki Hirayasu, Fumiji Saito, Tadahiro Suenaga, Kyoko Shida, Noriko Arase, Keita Oikawa, Toshifumi Yamaoka, Hiroyuki Murota, Hiroji Chibana, Ichiro Nakagawa, Tomoko Kubori, Hiroki Nagai, Yuji Nakamaru, Ichiro Katayama, Marco Colonna, Hisashi Arase. Nat Microbiol. 2016 Apr 25;1(6):16054. doi: 10.1038/nmicrobiol.2016.54.

Golgi-Resident GTPase Rab30 Promotes the Biogenesis of Pathogen-Containing Autophagosomes. Seiichiro Oda, Takashi Nozawa, Atsuko Nozawa-Minowa, Misako Tanaka, Chihiro Aikawa, Hiroyuki Harada, Ichiro Nakagawa. PLoS One. 2016 Jan 15;11(1):e0147061. doi: 10.1371/journal.pone.0147061.

Deep sequencing analysis of the heterogeneity of seed and commercial lots of the bacillus Calmette-Guérin (BCG) tuberculosis vaccine substrain Tokyo-172. Takayuki Wada, Fumito Maruyama, Tomotada Iwamoto, Shinji Maeda, Taro Yamamoto, Ichiro Nakagawa, Saburo Yamamoto, Naoya Ohara. Sci Rep. 2015 Dec 4;5:17827. doi: 10.1038/srep17827.

Characterization of 3 Megabase-Sized Circular Replicons from Vibrio cholerae. Kazuhisa Okada, Wirongrong Natakuathung, Mathukorn Na-Ubol, Amonrattana Roobthaisong, Warawan Wongboot, Fumito Maruyama, Ichiro Nakagawa, Siriporn Chantaroj, Shigeyuki Hamada. Emerg Infect Dis. 2015 Jul;21(7):1262-3. doi: 10.3201/eid2107.141055.

Genetic profiles of Propionibacterium acnes and identification of a unique transposon with novel insertion sequences in sarcoid and non-sarcoid isolates. Kana Minegishi, Takayasu Watanabe, Asuka Furukawa, Keisuke Uchida, Yoshimi Suzuki, Takumi Akashi, Fumito Maruyama, Ichiro Nakagawa, Yoshinobu Eishi. Sci Rep. 2015 May 12;5:9832. doi: 10.1038/srep09832.

Comparative genome analysis and identification of competitive and cooperative interactions in a polymicrobial disease. Akiko Endo, Takayasu Watanabe, Nachiko Ogata, Takashi Nozawa, Chihiro Aikawa, Shinichi Arakawa, Fumito Maruyama, Yuichi Izumi, Ichiro Nakagawa. ISME J. 2015 Mar;9(3):629-42. doi: 10.1038/ismej.2014.155.

Molecular and genomic characterization of pathogenic traits of group A Streptococcus pyogenes. Shigeyuki Hamada, Shigetada Kawabata, Ichiro Nakagawa. Proc Jpn Acad Ser B Phys Biol Sci. 2015;91(10):539-59. doi: 10.2183/pjab.91.539.

Rab17-mediated recycling endosomes contribute to autophagosome formation in response to Group A Streptococcus invasion. Bijaya Haobam, Takashi Nozawa, Atsuko Minowa-Nozawa, Misako Tanaka, Seiichiro Oda, Takayasu Watanabe, Chihiro Aikawa, Fumito Maruyama, Ichiro Nakagawa. Cell Microbiol. 2014 Dec;16(12):1806-21. doi: 10.1111/cmi.12329.

Intraindividual variation in core microbiota in peri-implantitis and periodontitis. Noriko Maruyama, Fumito Maruyama, Yasuo Takeuchi, Chihiro Aikawa, Yuichi Izumi, Ichiro Nakagawa. Sci Rep. 2014 Oct 13;4:6602. doi: 10.1038/srep06602.

The staphylococcal elastin-binding protein regulates zinc-dependent growth/biofilm formation. Makoto Nakakido, Chihiro Aikawa, Ichiro Nakagawa, Kouhei Tsumoto. J Biochem. 2014 Sep;156(3):155-62. doi: 10.1093/jb/mvu027.

Comparative genomic characterization of a Thailand-Myanmar isolate, MS6, of Vibrio cholerae O1 El Tor, which is phylogenetically related to a “US Gulf Coast” clone. Kazuhisa Okada, Mathukorn Na-Ubol, Wirongrong Natakuathung, Amonrattana Roobthaisong, Fumito Maruyama, Ichiro Nakagawa, Siriporn Chantaroj, Shigeyuki Hamada. PLoS One. 2014 Jun 2;9(6):e98120. doi: 10.1371/journal.pone.0098120.

Development of a two-step multiplex PCR assay for typing of capsular polysaccharide synthesis gene clusters of Streptococcus suis. Masatoshi Okura, Claude Lachance, Makoto Osaki, Tsutomu Sekizaki, Fumito Maruyama, Takashi Nozawa, Ichiro Nakagawa, Shigeyuki Hamada, Céline Rossignol, Marcelo Gottschalk, Daisuke Takamatsu. J Clin Microbiol. 2014 May;52(5):1714-9. doi: 10.1128/JCM.03411-13.

Genome Sequence of a Bacillus anthracis Outbreak Strain from Zambia, 2011. Naomi Ohnishi, Fumito Maruyama, Hirohito Ogawa, Hirokazu Kachi, Shunsuke Yamada, Daisuke Fujikura, Ichiro Nakagawa, Mudenda B Hang’ombe, Yuka Thomas, Aaron S Mweene, Hideaki Higashi. Genome Announc. 2014 Mar 6;2(2):e00116-14. doi: 10.1128/genomeA.00116-14.

Evaluation of biofilm formation in the presence of saliva on poly(ethylene glycol)deposited titanium. Ayako Kawabe, Ichiro Nakagawa, Zuisei Kanno, Yusuke Tsutsumi, Takao Hanawa, Takashi Ono. Dent Mater J. 2014;33(5):638-47. doi: 10.4012/dmj.2014-025.

Endogenous nitrated nucleotide is a key mediator of autophagy and innate defense against bacteria. Chiaki Ito, Yohei Saito, Takashi Nozawa, Shigemoto Fujii, Tomohiro Sawa, Hirofumi Inoue, Tetsuro Matsunaga, Shahzada Khan, Soichiro Akashi, Ryota Hashimoto, Chihiro Aikawa, Eriko Takahashi, Hiroshi Sagara, Masaaki Komatsu, Keiji Tanaka, Takaaki Akaike, Ichiro Nakagawa, Hirokazu Arimoto. Mol Cell. 2013 Dec 26;52(6):794-804. doi: 10.1016/j.molcel.2013.10.024.

Streptococcus pyogenes escapes from autophagy. Ichiro Nakagawa. Cell Host Microbe. 2013 Dec 11;14(6):604-6. doi: 10.1016/j.chom.2013.11.012.

Genetic analysis of capsular polysaccharide synthesis gene clusters from all serotypes of Streptococcus suis: potential mechanisms for generation of capsular variation. Masatoshi Okura, Daisuke Takamatsu, Fumito Maruyama, Takashi Nozawa, Ichiro Nakagawa, Makoto Osaki, Tsutomu Sekizaki, Marcelo Gottschalk, Yumi Kumagai, Shigeyuki Hamada. Appl Environ Microbiol. 2013 Apr;79(8):2796-806. doi: 10.1128/AEM.03742-12.

CRISPR regulation of intraspecies diversification by limiting IS transposition and intercellular recombination. Takayasu Watanabe, Takashi Nozawa, Chihiro Aikawa, Atsuo Amano, Fumito Maruyama, Ichiro Nakagawa. Genome Biol Evol. 2013;5(6):1099-114. doi: 10.1093/gbe/evt075.

Complete Genome Sequence of a Propionibacterium acnes Isolate from a Sarcoidosis Patient. Kana Minegishi, Chihiro Aikawa, Asuka Furukawa, Takayasu Watanabe, Tsubasa Nakano, Yoshitoshi Ogura, Yoshiyuki Ohtsubo, Ken Kurokawa, Tetsuya Hayashi, Fumito Maruyama, Ichiro Nakagawa, Yoshinobu Eishi. Genome Announc. 2013 Jan;1(1):e00016-12. doi: 10.1128/genomeA.00016-12.

Broad-range real-time PCR assay for detection of bacterial DNA in ocular samples from infectious endophthalmitis. Manabu Ogawa, Sunao Sugita, Norio Shimizu, Ken Watanabe, Ichiro Nakagawa, Manabu Mochizuki. Jpn J Ophthalmol. 2012 Nov;56(6):529-35. doi: 10.1007/s10384-012-0174-z.

The small GTPases Rab9A and Rab23 function at distinct steps in autophagy during Group A Streptococcus infection. Takashi Nozawa, Chihiro Aikawa, Akira Goda, Fumito Maruyama, Shigeyuki Hamada, Ichiro Nakagawa. Cell Microbiol. 2012 Aug;14(8):1149-65. doi: 10.1111/j.1462-5822.2012.01792.x.

Complete genome sequence of the serotype k Streptococcus mutans strain LJ23. Chihiro Aikawa, Nayuta Furukawa, Takayasu Watanabe, Kana Minegishi, Asuka Furukawa, Yoshinobu Eishi, Kenshiro Oshima, Ken Kurokawa, Masahira Hattori, Kazuhiko Nakano, Fumito Maruyama, Ichiro Nakagawa, Takashi Ooshima. J Bacteriol. 2012 May;194(10):2754-5. doi: 10.1128/JB.00350-12.

Genotypic and PFGE/MLVA analyses of Vibrio cholerae O1: geographical spread and temporal changes during the 2007-2010 cholera outbreaks in Thailand. Kazuhisa Okada, Amonrattana Roobthaisong, Ichiro Nakagawa, Shigeyuki Hamada, Siriporn Chantaroj. PLoS One. 2012;7(1):e30863. doi: 10.1371/journal.pone.0030863.

Transition metal ions induce carnosinase activity in PepD-homologous protein from Porphyromonas gingivalis. Akinobu Aoki, Yasuko Shibata, Soichiro Okano, Fumito Maruyama, Atsuo Amano, Ichiro Nakagawa, Yoshimitsu Abiko. Microb Pathog. 2012 Jan;52(1):17-24. doi: 10.1016/j.micpath.2011.09.003.

The collagen-binding protein of Streptococcus mutans is involved in haemorrhagic stroke. Kazuhiko Nakano, Kazuya Hokamura, Naho Taniguchi, Koichiro Wada, Chiho Kudo, Ryota Nomura, Ayuchi Kojima, Shuhei Naka, Yoshinori Muranaka, Min Thura, Atsushi Nakajima, Katsuhiko Masuda, Ichiro Nakagawa, Pietro Speziale, Nobumitsu Shimada, Atsuo Amano, Yoshinori Kamisaki, Tokutaro Tanaka, Kazuo Umemura, Takashi Ooshima. Nat Commun. 2011 Sep 27;2:485. doi: 10.1038/ncomms1491.

Cellular vacuolation induced by Clostridium perfringens epsilon-toxin. Masahiro Nagahama, Yukari Itohayashi, Hideki Hara, Masahiro Higashihara, Yusuke Fukatani, Teruhisa Takagishi, Masataka Oda, Keiko Kobayashi, Ichiro Nakagawa, Jun Sakurai. FEBS J. 2011 Sep;278(18):3395-407. doi: 10.1111/j.1742-4658.2011.08263.x.

Complete genome sequence of the bacterium Porphyromonas gingivalis TDC60, which causes periodontal disease. Takayasu Watanabe, Fumito Maruyama, Takashi Nozawa, Akinobu Aoki, Soichiro Okano, Yasuko Shibata, Kenshiro Oshima, Ken Kurokawa, Masahira Hattori, Ichiro Nakagawa, Yoshimitsu Abiko. J Bacteriol. 2011 Aug;193(16):4259-60. doi: 10.1128/JB.05269-11.

CRISPR inhibition of prophage acquisition in Streptococcus pyogenes. Takashi Nozawa, Nayuta Furukawa, Chihiro Aikawa, Takayasu Watanabe, Bijaya Haobam, Ken Kurokawa, Fumito Maruyama, Ichiro Nakagawa. PLoS One. 2011 May 6;6(5):e19543. doi: 10.1371/journal.pone.0019543.

Potent in vitro and in vivo antitumor effects of MDM2 inhibitor nutlin-3 in gastric cancer cells. Shinji Endo, Kenji Yamato, Sachiko Hirai, Toshikazu Moriwaki, Kuniaki Fukuda, Hideo Suzuki, Masato Abei, Ichiro Nakagawa, Ichinosuke Hyodo. Cancer Sci. 2011 Mar;102(3):605-13. doi: 10.1111/j.1349-7006.2010.01821.x.

Influence of Lactobacillus pentosus S-PT84 Ingestion on the Mucosal Immunity of Healthy and Salmonella Typhimurium-Infected Mice. Takayuki Izumo, Fumi Izumi, Ichiro Nakagawa, Yoshinori Kitagawa, Hiroshi Shibata, Yoshinobu Kiso. Biosci Microflora. 2011;30(2):27-35. doi: 10.12938/bifidus.30.27.

The dawning era of comprehensive transcriptome analysis in cellular microbiology. Chihiro Aikawa, Fumito Maruyama, Ichiro Nakagawa. Front Microbiol. 2010 Nov 5;1:118. doi: 10.3389/fmicb.2010.00118.

Specific behavior of intracellular Streptococcus pyogenes that has undergone autophagic degradation is associated with bacterial streptolysin O and host small G proteins Rab5 and Rab7. Atsuo Sakurai, Fumito Maruyama, Junko Funao, Takashi Nozawa, Chihiro Aikawa, Nobuo Okahashi, Seikou Shintani, Shigeyuki Hamada, Takashi Ooshima, Ichiro Nakagawa. J Biol Chem. 2010 Jul 16;285(29):22666-75. doi: 10.1074/jbc.M109.100131.

Reactive oxygen species induced by Streptococcus pyogenes invasion trigger apoptotic cell death in infected epithelial cells. Chihiro Aikawa, Takashi Nozawa, Fumito Maruyama, Kohei Tsumoto, Shigeyuki Hamada, Ichiro Nakagawa. Cell Microbiol. 2010 Jun;12(6):814-30. doi: 10.1111/j.1462-5822.2010.01435.x.

An initial step of GAS-containing autophagosome-like vacuoles formation requires Rab7. Hitomi Yamaguchi, Ichiro Nakagawa, Akitsugu Yamamoto, Atsuo Amano, Takeshi Noda, Tamotsu Yoshimori. PLoS Pathog. 2009 Nov;5(11):e1000670. doi: 10.1371/journal.ppat.1000670.

Listeria monocytogenes ActA-mediated escape from autophagic recognition. Yuko Yoshikawa, Michinaga Ogawa, Torsten Hain, Mitsutaka Yoshida, Makoto Fukumatsu, Minsoo Kim, Hitomi Mimuro, Ichiro Nakagawa, Toru Yanagawa, Tetsuro Ishii, Akira Kakizuka, Elizabeth Sztul, Trinad Chakraborty, Chihiro Sasakawa. Nat Cell Biol. 2009 Oct;11(10):1233-40. doi: 10.1038/ncb1967.

Comparative genomic analyses of Streptococcus mutans provide insights into chromosomal shuffling and species-specific content. Fumito Maruyama, Mitsuhiko Kobata, Ken Kurokawa, Keishin Nishida, Atsuo Sakurai, Kazuhiko Nakano, Ryota Nomura, Shigetada Kawabata, Takashi Ooshima, Kenta Nakai, Masahira Hattori, Shigeyuki Hamada, Ichiro Nakagawa. BMC Genomics. 2009 Aug 5;10:358. doi: 10.1186/1471-2164-10-358.

Cost effective DNA sequencing and template preparation from bacterial colonies and plasmids. Fumito Maruyama, Takashi Nozawa, Chihiro Aikawa, Atsuo Sakurai, Ichiro Nakagawa. J Biosci Bioeng. 2009 Apr;107(4):471-3. doi: 10.1016/j.jbiosc.2008.12.009.

Streptococcus-, Shigella-, and Listeria-induced autophagy. Michinaga Ogawa, Ichiro Nakagawa, Yuko Yoshikawa, Torsten Hain, Trinad Chakraborty, Chihiro Sasakawa. Methods Enzymol. 2009;452:363-81. doi: 10.1016/S0076-6879(08)03622-7.

Analysis of volatile metabolites from cultured bacteria by gas chromatography/atmospheric pressure chemical ionization-mass spectrometry. Masako Ishimaru, Masuyoshi Yamada, Ichiro Nakagawa, Sumio Sugano. J Breath Res. 2008 Sep;2(3):037021. doi: 10.1088/1752-7155/2/3/037021.

Streptococcus pyogenes degrades extracellular matrix in chondrocytes via MMP-13. Atsuo Sakurai, Nobuo Okahashi, Fumito Maruyama, Takashi Ooshima, Shigeyuki Hamada, Ichiro Nakagawa. Biochem Biophys Res Commun. 2008 Aug 29;373(3):450-4. doi: 10.1016/j.bbrc.2008.06.061.

Role of Hrs in maturation of autophagosomes in mammalian cells. Keiichi Tamai, Nobuyuki Tanaka, Atsuki Nara, Akitsugu Yamamoto, Ichiro Nakagawa, Tamotsu Yoshimori, Yoshiyuki Ueno, Tooru Shimosegawa, Kazuo Sugamura. Biochem Biophys Res Commun. 2007 Sep 7;360(4):721-7. doi: 10.1016/j.bbrc.2007.06.105.

Streptococcus mutans clonal variation revealed by multilocus sequence typing. Kazuhiko Nakano, Jinthana Lapirattanakul, Ryota Nomura, Hirotoshi Nemoto, Satu Alaluusua, Lisa Grönroos, Martti Vaara, Shigeyuki Hamada, Takashi Ooshima, Ichiro Nakagawa. J Clin Microbiol. 2007 Aug;45(8):2616-25. doi: 10.1128/JCM.02343-06.

Virulence of Porphyromonas gingivalis is altered by substitution of fimbria gene with different genotype. Takahiro Kato, Shinji Kawai, Kazuhiko Nakano, Hiroaki Inaba, Masae Kuboniwa, Ichiro Nakagawa, Kayoko Tsuda, Hiroko Omori, Takashi Ooshima, Tamotsu Yoshimori, Atsuo Amano. Cell Microbiol. 2007 Mar;9(3):753-65. doi: 10.1111/j.1462-5822.2006.00825.x.

Autophagy in innate immunity against intracellular bacteria. Atsuo Amano, Ichiro Nakagawa, Tamotsu Yoshimori. J Biochem. 2006 Aug;140(2):161-6. doi: 10.1093/jb/mvj162.

Invasion of epithelial cells and proteolysis of cellular focal adhesion components by distinct types of Porphyromonas gingivalis fimbriae. Ichiro Nakagawa, Hiroaki Inaba, Taihei Yamamura, Takahiro Kato, Shinji Kawai, Takashi Ooshima, Atsuo Amano. Infect Immun. 2006 Jul;74(7):3773-82. doi: 10.1128/IAI.01902-05.

Inhibitory effects of tumor necrosis factor-alpha on migration of human periodontal ligament cells. Akane Takemura, Ichiro Nakagawa, Shinji Kawai, Hiroaki Inaba, Takahiro Kato, Shigeyuki Hamada, Atsuo Amano. J Periodontol. 2006 May;77(5):883-90. doi: 10.1902/jop.2006.050192.

Helicobacter pylori vacuolating cytotoxin induces activation of the proapoptotic proteins Bax and Bak, leading to cytochrome c release and cell death, independent of vacuolation. Eiki Yamasaki, Akihiro Wada, Atsushi Kumatori, Ichiro Nakagawa, Junko Funao, Masaaki Nakayama, Junzo Hisatsune, Miyuki Kimura, Joel Moss, Toshiya Hirayama. J Biol Chem. 2006 Apr 21;281(16):11250-9. doi: 10.1074/jbc.M509404200.

Association between epithelial cell death and invasion by microspheres conjugated to Porphyromonas gingivalis vesicles with different types of fimbriae. Hiroaki Inaba, Shinji Kawai, Takahiro Kato, Ichiro Nakagawa, Atsuo Amano. Infect Immun. 2006 Jan;74(1):734-9. doi: 10.1128/IAI.74.1.734-739.2006.

Distribution of Porphyromonas gingivalis fimA genotypes in Japanese children and adolescents. Kiyoko Tamura, Kazuhiko Nakano, Ryota Nomura, Sonoko Miyake, Ichiro Nakagawa, Atsuo Amano, Takashi Ooshima. J Periodontol. 2005 May;76(5):674-9. doi: 10.1902/jop.2005.76.5.674.

Inhibitory effects of Porphyromonas gingivalis fimbriae on interactions between extracellular matrix proteins and cellular integrins. Ichiro Nakagawa, Atsuo Amano, Hiroaki Inaba, Shinji Kawai, Shigeyuki Hamada. Microbes Infect. 2005 Feb;7(2):157-63. doi: 10.1016/j.micinf.2004.10.007.

Molecular dissection of internalization of Porphyromonas gingivalis by cells using fluorescent beads coated with bacterial membrane vesicle. Kayoko Tsuda, Atsuo Amano, Kyohei Umebayashi, Hiroaki Inaba, Ichiro Nakagawa, Yoshinobu Nakanishi, Tamotsu Yoshimori. Cell Struct Funct. 2005;30(2):81-91. doi: 10.1247/csf.30.81.

Autophagy defends cells against invading group A Streptococcus. Ichiro Nakagawa, Atsuo Amano, Noboru Mizushima, Akitsugu Yamamoto, Hitomi Yamaguchi, Takahiro Kamimoto, Atsuki Nara, Junko Funao, Masanobu Nakata, Kayoko Tsuda, Shigeyuki Hamada, Tamotsu Yoshimori. Science. 2004 Nov 5;306(5698):1037-40. doi: 10.1126/science.1103966.

Development of a PCR method for rapid identification of new Streptococcus mutans serotype k strains. Kazuhiko Nakano, Ryota Nomura, Noriko Shimizu, Ichiro Nakagawa, Shigeyuki Hamada, Takashi Ooshima. J Clin Microbiol. 2004 Nov;42(11):4925-30. doi: 10.1128/JCM.42.11.4925-4930.2004.

Transcriptome analysis and gene expression profiles of early apoptosis-related genes in Streptococcus pyogenes-infected epithelial cells. Ichiro Nakagawa, Masanobu Nakata, Shigetada Kawabata, Shigeyuki Hamada. Cell Microbiol. 2004 Oct;6(10):939-52. doi: 10.1111/j.1462-5822.2004.00412.x.

Variations of Porphyromonas gingivalis fimbriae in relation to microbial pathogenesis. Atsuo Amano, Ichiro Nakagawa, Nobuo Okahashi, Nobushiro Hamada. J Periodontal Res. 2004 Apr;39(2):136-42. doi: 10.1111/j.1600-0765.2004.00719.x.

Porphyromonas gingivalis induces receptor activator of NF-kappaB ligand expression in osteoblasts through the activator protein 1 pathway. Nobuo Okahashi, Hiroaki Inaba, Ichiro Nakagawa, Taihei Yamamura, Masae Kuboniwa, Koji Nakayama, Shigeyuki Hamada, Atsuo Amano. Infect Immun. 2004 Mar;72(3):1706-14. doi: 10.1128/IAI.72.3.1706-1714.2004.

Demonstration of Streptococcus mutans with a cell wall polysaccharide specific to a new serotype, k, in the human oral cavity. Kazuhiko Nakano, Ryota Nomura, Ichiro Nakagawa, Shigeyuki Hamada, Takashi Ooshima. J Clin Microbiol. 2004 Jan;42(1):198-202. doi: 10.1128/JCM.42.1.198-202.2004.

Streptococcus pyogenes infection induces septic arthritis with increased production of the receptor activator of the NF-kappaB ligand. Atsuo Sakurai, Nobuo Okahashi, Ichiro Nakagawa, Shigetada Kawabata, Atsuo Amano, Takashi Ooshima, Shigeyuki Hamada. Infect Immun. 2003 Oct;71(10):6019-26. doi: 10.1128/IAI.71.10.6019-6026.2003.

Genome sequence of an M3 strain of Streptococcus pyogenes reveals a large-scale genomic rearrangement in invasive strains and new insights into phage evolution. Ichiro Nakagawa, Ken Kurokawa, Atsushi Yamashita, Masanobu Nakata, Yusuke Tomiyasu, Nobuo Okahashi, Shigetada Kawabata, Kiyoshi Yamazaki, Tadayoshi Shiba, Teruo Yasunaga, Hideo Hayashi, Masahira Hattori, Shigeyuki Hamada. Genome Res. 2003 Jun;13(6A):1042-55. doi: 10.1101/gr.1096703.

Influenza A virus-infected hosts boost an invasive type of Streptococcus pyogenes infection in mice. Shigefumi Okamoto, Shigetada Kawabata, Ichiro Nakagawa, Yoshinobu Okuno, Toshiyuki Goto, Kouichi Sano, Shigeyuki Hamada. J Virol. 2003 Apr;77(7):4104-12. doi: 10.1128/jvi.77.7.4104-4112.2003.

Infection by Streptococcus pyogenes induces the receptor activator of NF-kappaB ligand expression in mouse osteoblastic cells. Nobuo Okahashi, Atsuo Sakurai, Ichiro Nakagawa, Taku Fujiwara, Shigetada Kawabata, Atsuo Amano, Shigeyuki Hamada. Infect Immun. 2003 Feb;71(2):948-55. doi: 10.1128/IAI.71.2.948-955.2003.

Molecular characterization of a novel fibronectin-binding protein of Streptococcus pyogenes strains isolated from toxic shock-like syndrome patients. Yutaka Terao, Shigetada Kawabata, Masanobu Nakata, Ichiro Nakagawa, Shigeyuki Hamada. J Biol Chem. 2002 Dec 6;277(49):47428-35. doi: 10.1074/jbc.M209133200.

A novel, anchorless streptococcal surface protein that binds to human immunoglobulins. Shigetada Kawabata, Yasuharu Tamura, Jumpei Murakami, Yutaka Terao, Ichiro Nakagawa, Shigeyuki Hamada. Biochem Biophys Res Commun. 2002 Sep 6;296(5):1329-33. doi: 10.1016/s0006-291x(02)02078-8.

Infection and pathogenesis of a murine strain of Escherichia coli with genetically introduced Shiga toxin type I operon in conventional mice. Ichiro Nakagawa, Masanobu Nakata, Taihei Yamamura, Satoshi Wakisaka, Shigetada Kawabata, Shigeyuki Hamada. Microb Pathog. 2002 Aug;33(2):63-72. doi: 10.1006/mpat.2002.0518.

Novel laminin-binding protein of Streptococcus pyogenes, Lbp, is involved in adhesion to epithelial cells. Yutaka Terao, Shigetada Kawabata, Eiji Kunitomo, Ichiro Nakagawa, Shigeyuki Hamada. Infect Immun. 2002 Feb;70(2):993-7. doi: 10.1128/IAI.70.2.993-997.2002.

Functional differences among FimA variants of Porphyromonas gingivalis and their effects on adhesion to and invasion of human epithelial cells. Ichiro Nakagawa, Atsuo Amano, Masae Kuboniwa, Takayuki Nakamura, Shigetada Kawabata, Shigeyuki Hamada. Infect Immun. 2002 Jan;70(1):277-85. doi: 10.1128/IAI.70.1.277-285.2002.